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Table 2 Relationship between log CRP and Fetal ultrasound markers

From: Maternal cardiometabolic markers are associated with fetal growth: a secondary exploratory analysis of the LIMIT randomised trial

Ultrasound Measure

Unadjusted Estimate (95% CI)

Unadjusted p value

Adjusted Estimate (95% CI)

Adjusted p value

EFW

 

0.559*

 

0.835*

 - 28 Weeks

−6.41 (−26.19, 13.36)

0.525

−8.62 (−29.88, 12.63)

0.426

 - 36 Weeks

−17.06 (−53.13, 19.01)

0.354

−12.50 (−47.91, 22.90)

0.489

SSFM

 

0.842*

 

0.850*

 - 28 Weeks

−0.00 (− 0.10, 0.09)

0.920

0.02 (− 0.08, 0.11)

0.744

 - 36 Weeks

0.01 (− 0.14, 0.16)

0.875

0.03 (−0.12, 0.18)

0.675

AFM

 

0.442*

 

0.394*

 - 28 Weeks

0.00 (−0.10, 0.10)

0.990

−0.00 (− 0.11, 0.11)

0.976

 - 36 Weeks

0.07 (−0.09, 0.23)

0.396

0.08 (−0.08, 0.23)

0.353

MTFM

 

0.988*

 

0.998*

 - 28 Weeks

0.04 (−0.08, 0.17)

0.514

0.05 (−0.09, 0.19)

0.456

 - 36 Weeks

0.04 (−0.29, 0.37)

0.817

0.05 (−0.28, 0.39)

0.758

MTLM

 

0.419*

 

0.376*

 - 28 Weeks

0.04 (−0.06, 0.15)

0.414

0.05 (−0.06, 0.16)

0.367

 - 36 Weeks

−0.05 (− 0.28, 0.17)

0.636

− 0.06 (− 0.28, 0.17)

0.615

AC

 

0.698*

 

0.998*

 - 28 Weeks

−0.05 (− 0.20, 0.09)

0.473

− 0.07 (− 0.22, 0.08)

0.351

 - 36 Weeks

− 0.09 (− 0.26, 0.08)

0.296

−0.07 (− 0.24, 0.10)

0.407

BPD

 

0.114*

 

0.147*

 - 28 Weeks

− 0.03 (− 0.06, 0.00)

0.096

− 0.02 (− 0.06, 0.01)

0.167

 - 36 Weeks

0.00 (− 0.03, 0.03)

0.883

0.00 (− 0.03, 0.04)

0.770

HC

 

0.682*

 

0.568*

 - 28 Weeks

−0.07 (− 0.19, 0.05)

0.259

− 0.07 (− 0.19, 0.05)

0.280

 - 36 Weeks

− 0.04 (− 0.15, 0.07)

0.462

−0.03 (− 0.13, 0.08)

0.625

FL

 

0.961*

 

0.824*

 - 28 Weeks

− 0.01 (− 0.04, 0.02)

0.491

− 0.01 (− 0.04, 0.02)

0.428

 - 36 Weeks

−0.01 (− 0.04, 0.02)

0.478

− 0.01 (− 0.04, 0.02)

0.602

EFW z score

 

0.466*

 

0.587*

 - 28 Weeks

0.03 (− 0.04, 0.10)

0.380

0.02 (− 0.04, 0.09)

0.482

 - 36 Weeks

− 0.00 (− 0.08, 0.08)

0.981

0.00 (− 0.08, 0.08)

0.979

AC z score

 

0.611*

 

0.791*

 - 28 Weeks

0.02 (−0.06, 0.10)

0.609

0.01 (−0.07, 0.09)

0.808

 - 36 Weeks

−0.01 (− 0.10, 0.09)

0.900

− 0.00 (− 0.09, 0.09)

0.931

BPD z score

 

0.095*

 

0.169*

 - 28 Weeks

−0.05 (− 0.16, 0.06)

0.399

− 0.04 (− 0.15, 0.08)

0.544

 - 36 Weeks

0.05 (− 0.04, 0.15)

0.261

0.05 (− 0.05, 0.15)

0.302

HC z score

 

0.706*

 

0.637*

 - 28 Weeks

−0.00 (− 0.08, 0.08)

0.932

− 0.00 (− 0.09, 0.08)

0.914

 - 36 Weeks

0.01 (− 0.06, 0.09)

0.738

0.02 (− 0.06, 0.09)

0.674

FL z score

 

0.942*

 

0.827*

 - 28 Weeks

0.01 (−0.07, 0.09)

0.768

0.00 (−0.08, 0.09)

0.920

 - 36 Weeks

0.02 (−0.07, 0.11)

0.726

0.02 (−0.08, 0.11)

0.738

  1. Results are expressed as the expected difference (ratio) and 95% confidence intervals
  2. Adjusted analyses including BMI category (< 30 vs ≥30), study centre, parity (0 vs ≥1), age at consent, smoking status and SEIFA IRSD quintile
  3. * p value for test of time-by-log CRP interaction to test whether the association between fetal ultrasound measure and log CRP are different at 36 weeks to the association at 28 weeks