Table 1 Baseline characteristics
Characteristics | Biochemical adrenal insufficiency (n = 36) | No biochemical adrenal insufficiency (n = 92) | p-value |
|---|---|---|---|
Age (mean ± SD) (years) | 59.0 ± 17.0 | 55.2 ± 19.5 | 0.294 |
Male, n (%) | 17 (47.2) | 48 (52.1) | 0.431 |
Body weight (mean ± SD) (kg) | 53.8 ± 11.4 | 54.9 ± 14.3 | 0.712 |
Underlying diseases, n (%) | |||
-Hypertension | 9 (25.0) | 21 (22.8) | 0.790 |
-Coronary artery disease | 6 (16.7) | 10 (10.8) | 0.372 |
-Autoimmune disease | 2 (5.5) | 9 (9.7) | 0.447 |
-Malignancy | 3 (8.3) | 13 (14.1) | 0.370 |
-Chronic renal disease | 2 (5.6) | 6 (6.5) | 0.846 |
-Cirrhosis/liver disease | 4 (11.1) | 3 (3.3) | 0.073 |
Indication of tests, n (%) | |||
-History of exogenous steroid or traditional medicine use | 16 (44.4) | 22 (23.9) | 0.021 |
-Hyponatremia | 8 (22.2) | 11 (11.9) | 0.141 |
-Fatigue | 11 (30.5) | 21 (22.8) | 0.367 |
-Hypotension | 8 (22.2) | 14 (15.2) | 0.342 |
-Weight loss | 4 (11.1) | 4 (4.3) | 0.153 |
-Hypoglycemia | 1 (2.7) | 11 (11.9) | 0.104 |
Cushingoid appearance in patients with exogenous steroid and/or traditional medicine use, n (%) | 12 (33.3) | 6 (6.5) | < 0.001 |
Ward, n (%) | |||
-General medicine | 29 (80.6) | 76 (82.6) | |
-Surgery | 7 (19.4) | 16 (17.4) | 0.782 |
Inpatient diagnosis | |||
-Sepsis | 11 (30.6) | 25 (27.2) | |
-Non-sepsis | 25 (69.4) | 67 (72.8) | 0.701 |
Length of hospital stay (mean ± SD) (days) | 22.3 ± 24.1 | 39.8 ± 41.6 | 0.349 |
Baseline SBP (mean ± SD) (mmHg) | 109.9 ± 17.5 | 118.2 ± 21.9 | 0.060 |
Baseline DBP (mean ± SD) (mmHg) | 67.1 ± 10.2 | 71.2 ± 15.6 | 0.174 |
ACTH stimulation test dose, n (%) | |||
-1 μg | 18 (50.0) | 39 (42.4) | |
-250 μg | 18 (50.0) | 53 (57.6) | 0.432 |
Serum 0800 h cortisol (mean ± SD) (μg/dl) | 7.4 ± 3.2 | 10.3 ± 3.1 | < 0.001 |
Serum random cortisol (mean ± SD) (μg/dl) | 6.2 ± 3.4 | 11.6 ± 5.7 | < 0.001 |
Serum albumin (mean ± SD) (g/dl) | 2.9 ± 0.8 | 3.1 ± 0.7 | 0.162 |
Serum cholesterol (mean ± SD) (mg/dl) | 152.9 ± 45.6 | 146.0 ± 55.1 | 0.484 |
Serum sodium (mean ± SD) (mmol/L) | 135.0 ± 6.6 | 136.5 ± 6.2 | 0.225 |
Serum potassium (mean ± SD) (mmol/L) | 3.9 ± 0.6 | 3.9 ± 0.5 | 0.642 |
Serum creatinine (mean ± SD) (mg/dl) | 1.21 ± 1.1 | 1.23 ± 1.3 | 0.956 |
eGFR | 86.4 ± 43.7 | 99.1 ± 62.0 | 0.287 |