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Table 5 Risk of having metabolic syndrome according to quartiles of thyroid hormone parameters, in women

From: Thyroid function and metabolic syndrome in the population-based LifeLines cohort study

 

Quartile

MetS/Total, n (%)

model 1

model 2

model 3

model 4

TSH

1

388/3726 (10.4)

1

1

1

1

2

428/3710 (11.5)

1.122 (0.970–1.298)

1.149 (0.989–1.334)

1.192 (1.025–1.386)

1.162 (0.984–1.372)

3

451/3729 (12.1)

1.184 (1.025–1.367)

1.165 (1.005–1.351)

1.219 (1.049–1.417)

1.046 (0.885–1.236)

4

493/3735 (13.2)

1.308 (1.136–1.507) #

1.212 (1.053–1.061)

1.288 (1.110–1.494)

1.167 (0.990–1.375)

FT4

1

523/3784 (13.8)

1

1

1

1

2

417/3707 (11.2)

0.790 (0.689–0.907)

0.761 (0.660–0.876) #

0.757 (0.656–0.874) #

0.854 (0.728–1.002)

3

423/3624 (11.7)

0.824 (0.718–0.945)

0.762 (0.661–0.877) #

0.758 (0.657–0.874) #

0.900 (0.767–1.057)

4

397/3785 (10.5)

0.731 (0.636–0.840) #

0.651 (0.564–0.752) #

0.620 (0.535–0.717) #

0.819 (0.696–0.964)

FT3

1

317/3104 (10.2)

1

1

1

1

2

482/4361 (11.1)

1.095 (0.943–1.272)

1.179 (1.011–1.375)

1.154 (0.988–1.348)

1.095 (0.923–1.299)

3

521/3897 (13.4)

1.357 (1.170–1.574) #

1.644 (1.410–1.916) #

1.558 (1.334–1.819) #

1.515 (1.276–1.798) #

4

439/3538 (12.4)

1.245 (1.068–1.452)

1.819 (1.550–2.134) #

1.707 (1.451–2.008) #

1.622 (1.354–1.942) #

FT3FT4

1

374/3724 (10.0)

1

1

1

1

2

392/3718 (10.5)

1.056 (0.909–1.226)

1.227 (1.051–1.432)

1.217 (1.041–1.423)

1.241 (1.045–1.473)

3

438/3726 (11.8)

1.193 (1.031–1.381)

1.557 (1.337–1.813) #

1.539 (1.319–1.795) #

1.423 (1.201–1.687) #

4

556/3732 (14.9)

1.568 (1.364–1.803) #

2.372 (2.045–2.751) #

2.329 (2.004–2.705) #

1.798 (1.522–2.125) #

  1. Model 1: crude; model 2: adjusted for age; model 3: adjusted for age, current smoking and alcohol consumption
  2. model 4: adjusted for age, BMI, current smoking and alcohol consumption
  3. OR and 95% CI for metabolic syndrome were calculated using logistic regression models
  4. Significant associations (P < 0.001) are shown in bold