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Table 4 Results of genetic models for ERα XbaI, ERα PvuII, ERα G2014A, ERβ AluI and ERβ RsaI polymorphisms and osteoporosis susceptibility in postmenopausal women

From: Associations between ERα/β gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: a systematic review and meta-analysis

Comparison

N

Test of association

Model

Test of heterogeneity

Begg’s test

Egger’s test

OR

95% CI

P value

P value

I2 (%)

P value

P value

ERα XbaI

Overall

14

        

 X vs. x

 

1.21

0.73–2.00

0.455

R

< 0.001

96.4

0.584

0.955

 XX vs. xx

 

1.84

0.71–4.75

0.206

R

< 0.001

93.7

0.443

0.465

 Xx vs. xx

 

1.19

0.83–1.70

0.357

R

< 0.001

80.1

0.511

0.610

 Xx/XX vs. xx

 

1.34

0.82–2.18

0.240

R

< 0.001

90.4

0.661

0.545

 XX vs. Xx/xx

 

1.50

0.70–3.24

0.296

R

< 0.001

93.4

0.443

0.875

Caucasian

7

        

 X vs. x

 

1.15

0.76–1.74

0.510

R

< 0.001

88.0

  

 XX vs. xx

 

1.56

0.56–4.39

0.399

R

< 0.001

88.9

  

 Xx vs. xx

 

1.13

0.76–1.67

0.540

R

0.021

59.8

  

 Xx/XX vs. xx

 

1.24

0.76–2.01

0.387

R

< 0.001

76.2

  

 XX vs. Xx/xx

 

1.30

0.56–3.03

0.536

R

< 0.001

88.2

  

Asian

7

        

 X vs. x

 

1.23

0.47–3.25

0.668

R

< 0.001

98.0

  

 XX vs. xx

 

2.18

0.37–12.73

0.388

R

< 0.001

98.1

  

 Xx vs. xx

 

1.22

0.63–2.36

0.553

R

< 0.001

88.0

  

 Xx/XX vs. xx

 

1.39

0.56–3.46

0.481

R

< 0.001

94.6

  

 XX vs. Xx/xx

 

1.77

0.44–7.14

0.424

R

< 0.001

96.0

  

ERα PvuII

Overall

16

        

 P vs. p

 

0.96

0.71–1.29

0.769

R

< 0.001

92.3

0.753

0.616

 PP vs. pp

 

0.99

0.55–1.78

0.961

R

< 0.001

90.8

1.000

0.886

 Pp vs. pp

 

1.01

0.72–1.41

0.956

R

< 0.001

82.3

0.753

0.501

 PP/Pp vs. pp

 

0.97

0.65–1.43

0.868

R

< 0.001

88.7

0.893

0.539

 PP vs. Pp/pp

 

0.99

0.65–1.53

0.977

R

< 0.001

87.3

0.893

0.976

Caucasian

8

        

 P vs. p

 

0.95

0.71–1.26

0.716

R

< 0.001

79.2

  

 PP vs. pp

 

0.93

0.49–1.79

0.831

R

< 0.001

81.4

  

 Pp vs. pp

 

0.98

0.73–1.31

0.877

R

0.112

40.0

  

 PP/Pp vs. pp

 

0.97

0.67–1.39

0.861

R

0.008

63.5

  

 PP vs. Pp/pp

 

0.97

0.59–1.58

0.895

R

< 0.001

78.2

  

Asian

8

        

 P vs. p

 

0.97

0.57–1.66

0.919

R

< 0.001

95.6

  

 PP vs. pp

 

1.08

0.40–2.96

0.877

R

< 0.001

94.4

  

 Pp vs. pp

 

1.04

0.58–1.88

0.889

R

< 0.001

90.2

  

 PP/Pp vs. pp

 

0.98

0.50–1.95

0.962

R

< 0.001

93.8

  

 PP vs. Pp/pp

 

1.05

0.50–2.20

0.891

R

< 0.001

91.8

  

 ERα G2014A

Overall

4

        

 A vs. G

 

0.89

0.32–2.51

0.825

R

< 0.001

95.1

0.308

0.237

 AA vs. GG

 

0.88

0.08–9.19

0.912

R

< 0.001

92.9

0.734

0.419

 GA vs. GG

 

0.76

0.28–2.03

0.581

R

< 0.001

88.1

0.734

0.530

 GA/AA vs. GG

 

0.73

0.22–2.41

0.601

R

< 0.001

92.8

0.734

0.530

 AA vs. GA/GG

 

1.13

0.23–5.72

0.878

R

< 0.001

88.6

0.734

0.299

Caucasian

1

        

 A vs. G

 

0.63

0.41–0.96

0.032

R

–

–

  

 AA vs. GG

 

0.28

0.07–1.21

0.089

R

–

–

  

 GA vs. GG

 

0.66

0.39–1.11

0.116

R

–

–

  

 GA/AA vs. GG

 

0.60

0.36–1.00

0.050

R

–

–

  

 AA vs. GA/GG

 

0.34

0.08–1.43

0.141

R

–

–

  

Asian

3

        

 A vs. G

 

1.00

0.23–4.46

0.996

R

< 0.001

96.6

  

 AA vs. GG

 

1.28

0.05–30.10

0.878

R

< 0.001

95.2

  

 GA vs. GG

 

0.77

0.17–3.45

0.736

R

< 0.001

91.3

  

 GA/AA vs. GG

 

0.76

0.12–4.62

0.765

R

< 0.001

94.8

  

 AA vs. GA/GG

 

1.69

0.20–14.27

0.630

R

< 0.001

92.2

  

ERβ AluI

Overall

4

        

 A vs. G

 

1.25

0.78–2.00

0.362

R

< 0.001

91.5

1.000

0.997

 AA vs. GG

 

1.27

0.52–3.13

0.597

R

< 0.001

88.4

0.734

0.647

 GA vs. GG

 

1.16

0.65–2.07

0.606

R

0.001

81.0

0.734

0.408

 GA/AA vs. GG

 

1.29

0.66–2.53

0.459

R

< 0.001

87.8

0.734

0.612

 AA vs. GA/GG

 

1.21

0.65–2.24

0.553

R

< 0.001

85.7

0.497

0.646

Caucasian

3

        

 A vs. G

 

1.23

0.58–2.57

0.590

R

< 0.001

94.3

  

 AA vs. GG

 

1.28

0.34–4.84

0.717

R

< 0.001

92.2

  

 GA vs. GG

 

1.30

0.60–2.78

0.504

R

0.001

86.5

  

 GA/AA vs. GG

 

1.36

0.55–3.39

0.507

R

< 0.001

91.8

  

 AA vs. GA/GG

 

1.10

0.37–3.22

0.863

R

< 0.001

90.3

  

Asian

1

        

 A vs. G

 

1.31

1.06–1.62

0.012

R

–

–

  

 AA vs. GG

 

1.24

0.72–2.13

0.441

R

–

–

  

 GA vs. GG

 

0.84

0.48–1.48

0.548

R

–

–

  

 GA/AA vs. GG

 

1.10

0.64–1.87

0.739

R

–

–

  

 AA vs. GA/GG

 

1.44

1.12–1.84

0.004

R

–

–

  

ERβ RsaI

Overall

2

        

 A vs. G

 

0.92

0.50–1.70

0.785

R

0.010

85.0

  

 AA vs. GG

 

0.49

0.34–0.70

< 0.001

F

0.261

20.9

  

 GA vs. GG

 

0.87

0.41–1.84

0.722

R

< 0.001

85.9

  

 GA/AA vs. GG

 

0.85

0.37–1.95

0.704

R

< 0.001

88.9

  

 AA vs. GA/GG

 

0.66

0.48–0.90

0.009

F

0.408

0

  

Caucasian

1

        

 A vs. G

 

1.30

0.83–2.04

0.245

R

–

–

  

 AA vs. GG

 

1.92

0.17–21.41

0.596

F

–

–

  

 GA vs. GG

 

1.32

0.80–2.15

0.273

R

–

–

  

 GA/AA vs. GG

 

1.33

0.82–2.17

0.246

R

–

–

  

 AA vs. GA/GG

 

1.81

0.16–20.11

0.630

F

–

–

  

Asian

1

        

 A vs. G

 

0.69

0.58–0.82

< 0.001

R

–

–

  

 AA vs. GG

 

0.47

0.33–0.68

< 0.001

F

–

–

  

 GA vs. GG

 

0.61

0.47–0.81

< 0.001

R

–

–

  

 GA/AA vs. GG

 

0.57

0.44–0.74

< 0.001

R

–

–

  

 AA vs. GA/GG

 

0.65

0.47–0.89

0.007

F

–

–

  
  1. R Random effect model
  2. F Fixed effect model
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