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Table 1 Serum levels of procollagen type I amino-terminal propeptide (PINP), osteocalcin and C-telopeptide of type I collagen (CTX), testosterone, estradiol, estrone sulfate, sex hormone-binding globulin (SHBG) and serotonin measured in the fasting state on each of the study days

From: No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course

 

Day 0

 

Day 4

 

Day 8

 

Day 42

 

Day 180

 

P1NP (ug/l)

108

(81–136)

116

(81–150)

114

(76–152)

104

(75–134)

113

(84–142)

Osteocalcin (ug/l)

35

(28–42)

37

(30–45)

36

(28–43)

33

(26–40)

35

(25–45)

CTX-1 (ug/l)

0.98

(0.68–1.29)

0.98

(0.72–1.24)

0.91

(0.64–1.17)

0.94

(0.67–1.21)

0.87

(0.58–1.15)

Testosterone (nmol/l)

19

(16–22)

21

(17–25)

23

(19–27)

21

(18–24)

26

(16–35)

Estradiol (pmol/l)

93

(75–112)

91

(68–114)

83

(63–103)

90

(70–110)

88

(59–117)

Estrone sulfate (umol/l)

19.7

(11.8–27.6)

15.7

(97.3–21.7)

22.1

(10.0–34.2)

20.3

(81.6–32.5)

22.8

(12.7–32.9)

SHBG (nmol/l)

34

(22–46)

36

(24–48)

40†

(28–52)

34

(23–45)

36

(26–46)

Serotonin (ng/ml)

164

(92–236)

178

(95–261)

199

(116–282)

180

(101–258)

221

(139–303)

  1. Data are expressed as mean with 95% confidence intervals in brackets. † denotes p < 0.05 (following correction for multiple comparisons), indicating a significant change compared to day 0