Table 3 Association of circulating day-time and night-time serum cortisone (AUC) and total cortisol (AUC) with bone turnover markers in patients receiving hydrocortisone
All patients on HC Spearman Correlation (r) | Day-time Cortisone (AUC) r value, (p value) | Day-time Cortisol (AUC) r value, (p value) | Night-time Cortisone (AUC) r value, (p value) | Night-time Cortisol (AUC) r value, (p value) |
|---|---|---|---|---|
Bone Formation | ||||
 OC[1–49] (μg/l) | −0.23, (p = 0.25) | −0.23, (p = 0.25) | −0.41, (p = 0.03)* | −0.36, (p = 0.07) |
 PINP (μg/l) | − 0.28, (p = 0.16) | −0.28, (p = 0.16) | −0.34, (p = 0.08) | −0.38, (p = 0.04)* |
 Bone ALP (μg/l) | − 0.08, (p = 0.7) | −0.0778, (p = 0.7) | − 0.03, (p = 0.9) | 0.013, (p = 0.95) |
Bone Resorption | ||||
 CTX-I (μg/l) | − 0.14, (p = 0.50) | −0.14, (p = 0.50) | −0.34, (p = 0.08) | −0.28, (p = 0.16) |
 TRACP5b (IU/l) | − 0.19, (p = 0.32) | −0.19, (p = 0.32) | 0.021, (p = 0.92) | −0.12, (p = 0.55) |
 PINP:CTX-I ratio | − 0.28, (p = 0.14) | −0.29, (p = 0.14) | −0.12, (p = 0.55) | −0.29, (p = 0.13) |