Table 4 Association of urinary steroid metabolites with bone turnover markers in patients receiving hydrocortisone. Total urinary F metabolites = Total urinary cortisol metabolites; Andro = androsterone; Etio = etiocholanolone *p < 0.05
All patients on HC replacement (n = 30) Urinary metabolites: r value (p value) | Total urinary F metabolites | THF + aTHF /THE | UFF/UFE | 5a THF/THF | Andro/Etio |
|---|---|---|---|---|---|
Bone Formation | |||||
 OC[1–49] (μg/l) | −0.35, (p = 0.06) | − 0.12, (p = 0.53) | 0.09, (p = 0.62) | 0.35, (p = 0.06) | 0.5, (p = 0.004)* |
 PINP (μg/l) | −0.39, (p = 0.04)* | −0.18, (p = 0.32) | 0.08, (p = 0.66) | 0.35, (p = 0.06) | 0.5, (p = 0.004)* |
 Bone ALP (μg/l) | −0.02, (p = 0.93) | −0.18, (p = 0.35) | 0.29, (p = 0.11) | −0.07, (p = 0.7) | 0.13, (p = 0.49) |
Bone Resorption | |||||
 CTX-I (μg/l) | −0.15, (p = 0.42) | −0.18, (p = 0.35) | 0.17, (p = 0.36) | 0.17, (p = 0.38) | 0.30, (p = 0.1) |
 TRACP5b (IU/l) | −0.14, (p = 0.46) | −0.31, (p = 0.09) | 0.18, (p = 0.35) | −0.8, (p = 0.66) | 0.18, (p = 0.33) |
 PINP: CTX-I ratio | −0.41, (p = 0.02)* | −0.15, (p = 0.45) | − 0.04, (p = 0.83) | 0.37, (p = 0.04)* | 0.58, (p = 0.008)* |