Fig. 3

Findings of endocrine function tests 2. (a) ACTH and (b) cortisol responses to a CRH (100 μg, i.v.) stimulation test. In both cases, a closed circle (solid line) indicates the value at 63 years of age, compared to results at 58 years of age (open circles and dashed lines). (c) Insulin tolerance test. ACTH response to insulin (0.05 units/kg bodyweight, i.v.). (d) Rapid ACTH stimulation test. Cortisol response to ACTH (tetracosactide acetate 0.28 mg, i.v.). (e) Prolonged ACTH simulation test. Cortisol response to ACTH (tetracosactide acetate, 0.56 mg, i.m.). c, d, and e all show data at 63 years of age. ACTH, adrenocorticotropic hormone; CRH, corticotropin-releasing hormone; i.v., intravenous; i.m., intramuscular