Fig. 4
From: Apoplexy of Crooke cell tumour leading to the diagnosis of severe Cushing disease; a case report
Low power view of H&E staining of surgical specimen showing features suggestive of pituitary neuroendocrine tumour and areas of necrosis and haemorrhage (a). High power view of H&E shows cells with basophilic, granular cytoplasm and round nuclei. Some cells showed homogenous pink cytoplasm. b. Immunohistochemistry with ACTH staining shows margination of ACTH reactivity to the cell periphery and perinuclear region (c). Cytokeratin stain (AE1/AE3) shows diffuse ring like positivity in majority of the cells (d)