SNP rs11185644 in RXRA gene and SNP rs2235544 in DIO1 gene predict dosage requirements in a cross-sectional sample of hypothyroid patients

Table 4 Linear regression analysis to find independent predictors of dose/weight level in hypothyroid patients treated with Levothyroxine. Only statistically significant variables are presented

Variable	Coefficient	95% Confidence interval		P Value
		Lower bound	Upper bound
(Constant)	3.222	1.961	4.483	0.000
rs11185644 CT Vs other genotypes	0.348	0.103	0.593	0.006
Disease Duration (years)	0.027	0.007	0.047	0.008
Age for DOB	-0.014	− 0.023	-0.005	0.003
Free Triiodothyronine (FT3), serum level pmol/L SI UNIT	-0.434	-0.678	-0.190	0.001
rs2235544 CC VS. Other genotypes	0.296	0.035	0.557	0.027

R square = 0.368, P value = 0.000
Criteria: Stepwise (Criteria: Probability-of-F-to-enter < = 0.050, Probability-of-F-to-remove > = 0.100).
Equation to calculate predicted dose (mcg/kg) levels = 3.22+ (0.348 for CT genotype of rs11185644) + 0.027*disease duration- 0.014*age- 0.434*T3 levels+ (0.296 for CC genotype of rs2235544)
All Variables studied: All 8 SNPs, sex, age, TPO status, adherence, smoking status, T3, TSH, T4 Supplementation status of VD, B12 and other supplements, family history, vitamin D level, b12 level, Ca level

ISSN: 1472-6823