SNP rs11185644 in RXRA gene and SNP rs2235544 in DIO1 gene predict dosage requirements in a cross-sectional sample of hypothyroid patients

Table 5 Linear regression analysis to find independent predictors of T3 level in hypothyroid patients treated with Levothyroxine. Only statistically significant variables are presented

Variable	Coefficient	95% Confidence interval		P Value
		Lower bound	Upper bound
(Constant)	3.674	2.873	4.474	0.000
Age for DOB	-0.013	-0.019	-0.006	0.000
Weekly dose of thyroxine (mg)	-0.001	-0.001	0.000	0.002
DIO1Rs2235544 CC VS. Other genotypes	0.375	0.165	0.584	0.001
Other supplements	0.345	0.125	0.565	0.003
Sex	0.493	0.065	0.921	0.025
Supplementation of VD	0.210	0.009	0.411	0.041

R square = 0.525, P value = 0.000
Criteria: Stepwise (Criteria: Probability-of-F-to-enter < = 0.050, Probability-of-F-to-remove > = 0.100).
Predicted T3 levels = 3.674 − 0.013*Age- 0.001*weekly dose of thyroxine +(0.375 For CC genotype of rs2235544) + 0.345* supplement status (1 for yes, 0 for No) + 0.493 (sex) + 0.21* supplementation status of VD (1 for yes, 0 for No)
All Variables studies: All 8 SNPs, sex, age, BMI, TPO status, adherence, smoking status, T3, TSH, Supplementation status of VD, B12 and other supplements, family history, vitamin D level, b12 level, Ca level

ISSN: 1472-6823