SNP rs11185644 in RXRA gene and SNP rs2235544 in DIO1 gene predict dosage requirements in a cross-sectional sample of hypothyroid patients

Table 6 Linear regression analysis to find independent predictors of T4 level in hypothyroid patients treated with Levothyroxine. Only statistically significant variables are presented

Variable	Coefficient	95% Confidence interval		P Value
		Lower bound	Upper bound
(Constant)	18.911	17.081	20.741	0.000
UGT1A3rs3806596 TT VS. other genotypes	-3.281	-5.292	-1.271	0.002
Weekly dose of thyroxine (mg)	0.003	0.001	0.005	0.004
Thyroid Stimulating Hormone (TSH), Serum mU/L SI UNIT	-0.771	-1.461	-0.082	0.029

R square = 0.311, P value = 0.000
Criteria: Stepwise (Criteria: Probability-of-F-to-enter < = 0.050, Probability-of-F-to-remove > = 0.100).
Equation to calculate Predicted T4 levels = 18.911- (3.281 For TT genotype of rs3806596) + 0.005* weekly dose of thyroxine − 0.771* TSH level
All Variables studied: All 8 SNPs, sex, age, BMI, TPO status, adherence, smoking status, T3, TSH, Supplementation status of VD, B12 and other supplements, family history, vitamin D level, b12 level, Ca level

ISSN: 1472-6823