SNP rs11185644 in RXRA gene and SNP rs2235544 in DIO1 gene predict dosage requirements in a cross-sectional sample of hypothyroid patients

Table 7 Linear regression analysis to find independent predictors of TSH level in hypothyroid patients treated with Levothyroxine. Only statistically significant variables are presented

Variable	Coefficient	95% Confidence interval		P Value
		Lower bound	Upper bound
(Constant)	3.896	2.583	5.208	0.000
Free Thyroxine (FT4), serum level pmol/L	-0.124	-0.193	-0.055	0.001
VDrs11185644CT Vs other genotypes	0.547	0.104	0.990	0.016

R square = 0.203, P value = 0.001
Criteria: Stepwise (Criteria: Probability-of-F-to-enter < = 0.050, Probability-of-F-to-remove > = 0.100).
Equation to calculate Predicted TSH levels = 3.896 − 0.124* T4 level + (0.547 for CT genotype of rs11185644)
All Variables studies: All 8 SNPs, sex, age, BMI, TPO status, adherence, smoking status, T3, TSH, Supplementation status of VD, B12 and other supplements, family history, vitamin D level, b12 level, Ca level

ISSN: 1472-6823