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Table 3 Measurements of platelet behavioural parameters in the DPFA in healthy controls compared to GHD pre and post GHT.

From: The modulation of platelet function by growth hormone in growth hormone deficient Hypopituitary patients

Parameter

Healthy Control

(n = 12)

Pre GH therapy

(n = 12)

Post GH therapy

(n = 12)

P value

(ANOVA)

Platelet Tethering

    

- Tracks (n)

356 ± 42

634 ± 86

621 ± 83

0.04*

Platelet Rolling

    

- Translocation Distance (µm)

- Translocation speed (µm/s)

- Translocating Platelets (n)

13.05 ± 1.6

7.45 ± 1.3

248 ± 32

13.14 ± 0.7

8.16 ± 1

449 ± 63

16.99 ± 0.9

10.63 ± 0.89

460 ± 59

0.01*

0.03*

0.009**

Platelet Adhesion

    

- Static platelets (n)

- Adhesion Rate

- % Platelet Surface Coverage

175 ± 16

0.33 ± 0.02

8.67 ± 0.58

256 ± 21

0.43 ± 0.03

10.28 ± 0.55

214 ± 27

0.37 ± 0.03

9.9 ± 0.69

0.04*

0.14

0.11

  1. Results are expressed as the mean ± SD and were compared by one way ANOVA for GHD cohorts, pre and post GHT vs. healthy controls. Values were considered statistically significant where p < 0.05*, < 0.01**