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Table 4 Relationship between Cre/BW ratio and the incident diabetes in different models

From: The association between creatinine to body weight ratio and the risk of progression to diabetes from pre-diabetes: a 5-year cohort study in Chinese adults

Exposure

Model I (HR,95%CI,P)

Model II (HR,95%CI,P)

Model III (HR,95%CI,P)

Model IV (HR,95%CI, P)

Cre/BW ratio

0.387 (0.321, 0.466) < 0.0001

0.235 (0.191, 0.288) < 0.0001

0.445 (0.361, 0.548) < 0.0001

0.521 (0.420, 0.646) < 0.0001

Cre/BW ratio Deciles

 D1

Ref

Ref

Ref

Ref

 D2

0.744 (0.640, 0.864) 0.00011

0.695 (0.597, 0.808) < 0.0001

0.817 (0.701, 0.951) 0.00902

0.819 (0.703, 0.955) 0.01063

 D3

0.704 (0.604, 0.820) < 0.0001

0.624 (0.535, 0.728) < 0.0001

0.742 (0.635, 0.867) 0.00017

0.750 (0.641, 0.877) 0.00032

 D4

0.708 (0.608, 0.825) < 0.0001

0.607 (0.519, 0.709) < 0.0001

0.768 (0.656, 0.899) 0.00102

0.772 (0.659, 0.905) 0.00143

 D5

0.595 (0.507, 0.699) < 0.0001

0.508 (0.432, 0.599) < 0.0001

0.671 (0.568, 0.792) < 0.0001

0.692 (0.585, 0.818) 0.00002

 D6

0.539 (0.458, 0.635) < 0.0001

0.450 (0.380, 0.532) < 0.0001

0.574 (0.485, 0.680) < 0.0001

0.608 (0.512, 0.722) < 0.0001

 D7

0.580 (0.492, 0.685) < 0.0001

0.464 (0.392, 0.551) < 0.0001

0.666 (0.560, 0.792) < 0.0001

0.703 (0.591, 0.837) 0.00007

 D8

0.544 (0.461, 0.643) < 0.0001

0.422 (0.355, 0.503) < 0.0001

0.614 (0.515, 0.733) < 0.0001

0.644 (0.538, 0.770) < 0.0001

 D9

0.533 (0.449, 0.633) < 0.0001

0.386 (0.323, 0.462) < 0.0001

0.582 (0.484, 0.700) < 0.0001

0.643 (0.534, 0.775) < 0.0001

 D10

0.472 (0.394, 0.565) < 0.0001

0.319 (0.264, 0.387) < 0.0001

0.523 (0.429, 0.637) < 0.0001

0.584 (0.477, 0.714) < 0.0001

Age

 

1.031 (1.027, 1.034) < 0.0001

1.024 (1.020, 1.027) < 0.0001

 

Gender

 Male

 

Ref

Ref

 

 Female

 

0.603 (0.527, 0.691) < 0.0001

0.790 (0.687, 0.908) 0.00088

 

Height(cm)

 

0.989 (0.982, 0.996) 0.00334

0.996 (0.988, 1.003) 0.21579

 

SBP(mmHg)

 

1.005 (1.002, 1.008) 0.00054

1.001 (0.999, 1.004) 0.33945

 

DBP(mmHg)

 

1.003 (0.999, 1.008) 0.15860

1.003 (0.998, 1.007) 0.22657

 

Smoking status

 Never smoker

 

Ref

Ref

 

 Ever smoker

 

1.191 (0.987, 1.438) 0.06832

1.038 (0.860, 1.253) 0.69817

 

 Current smoker

 

1.134 (1.028, 1.251) 0.01200

1.117 (1.010, 1.234) 0.03054

 

Drinking status

 Never drinker

 

Ref

Ref

 

 Ever drinker

 

0.899 (0.801, 1.010) 0.07255

0.954 (0.850, 1.071) 0.42675

 

 Current drinker

 

0.958 (0.801, 1.147) 0.64185

0.834 (0.694, 1.003) 0.05340

 

Family history of diabetes

 No

 

Ref

Ref

 

 Yes

 

1.687 (1.386, 2.053) < 0.0001

1.566 (1.286, 1.907) < 0.0001

 

FPG(mmol/L)

  

7.333 (6.614, 8.131) < 0.0001

 

TG(mmol/L)

  

1.052 (1.028, 1.077) < 0.0001

 

LDL-c(mmol/L)

  

0.941 (0.890, 0.995) 0.03138

 

HDL-c(mmol/L)

  

1.591 (1.394, 1.816) < 0.0001

 

ALT(U/L)

  

1.008 (1.005, 1.010) < 0.0001

 

AST(U/L)

  

0.994 (0.988, 1.000) 0.04987

 

BUN(mmol/L)

  

0.967 (0.935, 1.000) 0.05346

 
  1. Model I: we did not adjust other covariates
  2. Model II: we adjust age, gender, height, SBP, DBP, family history of diabetes, smoking and drinking status
  3. Model III: we adjust age, gender, height, SBP, DBP, FPG, BUN, TG, HDL-c, LDL-c, ALT, AST, family history of diabetes, smoking and drinking status
  4. Model IV: we adjusted age(smooth), gender, height(smooth), SBP(smooth), DBP(smooth), FPG(smooth), BUN(smooth), TG(smooth), HDL-c(smooth), LDL-c(smooth), ALT(smooth), AST(smooth), family history of diabetes, smoking and drinking status
  5. HR Hazard ratios, CI Confidence, Ref Reference, Cre/BW ratio Creatinine to body weight ratio
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BMC Endocrine Disorders

ISSN: 1472-6823

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