From: Circulating levels of asprosin in children with obesity: a systematic review and meta-analysis
Study | Design; setting | Obesity criterion for inclusion | Sample and Methods | Case group | Control group | ||||
---|---|---|---|---|---|---|---|---|---|
Sample size | Average BMI (kg/m2) and age (yrs) | Biomarkers | Sample size | Average BMI (kg/m2) and age (yrs) | Biomarkers | ||||
Corica et al., 2021 [20] | Single-center, cross-sectional, case-controlled study; Italy | BMI ≥  + 2 SDS, in accordance with definition of obesity by WHO for children from the age of 5 years [24]. | Serum (overnight fasting at least 8 h); ELISA | 43 m/f: 21/22; Pre-p/p:17 /26 | BMI ≥  + 2 SDS; Age: (11.9 ± 2.1) yrs | Asprosin:(331.9 ± 120.5) pg/mL | 24 m/f: 7/17 Pre-p/p:10/14 | BMI <  + 2 SDS; Age: (10.7 ± 2.9) yrs | Asprosin:(358.1 ± 74.1) pg/mL |
Long et al., 2019 [19] | Single-center, cross-sectional, case-controlled study; China | BMI greater than the age- and sex-appropriate 95th percentile based on the criteria of the BMI growth reference for Chinese children aged 0–18 years [25, 26]. | Plasma (overnight fasting at least 12 h); ELISA | 47 m/f: 26/21 | Boys: BMI (24.77 ± 2.33) kg/m2; BMI SDS:(2.09 ± 0.47); Age: (11.04 ± 1.34) yrs.; Girls: BMI (20.80 ± 4.99) kg/m2; BMI SDS: (2.22 ± 1.08); Age: (8.29 ± 1.21) yrs | Asprosin:(9.24 ± 4.11) ng/mL | 40 m/f: 23/17 | Boys: BMI (16.17 ± 2.34) kg/m2; BMI SDS:(–0.52 ± 0.84); Age: (10.31 ± 1.76) yrs Girls: BMI (15.36 ± 1.61) kg/m2; BMI SDS: (–0.27 ± 0.95); Age: (8.91 ± 1.42) yrs | Asprosin:(12.33 ± 4.18) ng/mL |
Wang et al., 2019 [15] | Single-center, cross-sectional, case-controlled study; China | BMI exceeded 95% of the normal level for a child of that age, according to the BMI reference criteria for Chinese children [27]. The BMI data were standardized to age-specific and sex-specific centiles based on the Working Group on Obesity in China Normal weight and were given as BMI SDS. WHR was calculated as waist (cm) divided by height (cm). | Serum (overnight fasting at least 12 h); ELISA | 79 m/f: 56/23 Pre-p/p:38/41 | BMI (27.44 ± 3.93) kg/m2; BMI SDS (2.88 ± 0.59); Age: (10.82 ± 2.12) yrs | Asprosin: 1.51 ± 0.44 ng/mL; TNF-α: 11.67 ± 5.31 pg/mL; Adiponectin:3.08 ± 1.41lg/mL; leptin: 71.89 (44.32–87.00) ng/mL | 40 m/f: 20/20; Pre-p/p:21/19 | BMI (15.67 ± 2.30) kg/m2; BMI SDS (–1.00 ± 1.02); Age: (10.94 ± 2.19) yrs | Asprosin: 0.96 ± 0.48 ng/mL; TNF-α: 3.97 ± 1.95 pg/mL; Adiponectin: 3.92 ± 1.74 lg/mL; Leptin: 7.07 (3.56–10.88) ng/mL |
Silistre et al., 2020 [16] | Prospective study; Turkey | According to WHO Reference 2017 [24]: Low weight (BMI-SDS ≤ -1); normal weight (BMI-SDS >—1 and ≤ 1; overweight (BMI SDS > 1 and ≤ 2) and obesity (BMI-SDS > 2). | Serum (overnight fasting at least 12 h); ELISA | 44 m/f: 20/24 | BMI: 29.585(20.56) kg/m2; BMI SDS: 2.475(1.61); Age: (12.196 ± 2.62) yrs | Asprosin: 106.293 ± 122.69 ng/mL | 60 m/f:32/28 | BMI: 19.745 (7.82) kg/m2; BMI SDS: -.035(1.94); Age: (12.921 ± 2.51) yrs | Asprosin: 70.903 ± 17.49 ng/mL; |
Liu et al., 2021 [17] | Single-center, cross-sectional, case-controlled study; China | According to the BMI reference for Chinese children, children with a BMI > 95% for their age and sex were diagnosed as having obesity. The BMI data were standardized to age- and sex-specific centiles and were converted into BMI SDS) [27]. | Serum (overnight fasting at least 12 h); ELISA | 75 m/f:52/26 | BMI: (27.06 ± 3.24) kg/m2; BMI SDS: (3.514 ± 1.1); Age: (10.752 ± 2.02) yrs | Asprosin: 1.356 ± 0.419 μg/mL; TNF-α: 5.32 ± 4.90 pg/mL; Adiponectin:3.33 ± 1.50 μg/mL | 35 m/f:19/16 | BMI: (15.79 ± 2.28) kg/m2; BMI SDS: (− 0.53 ± 0.58); Age: (10.95 ± 2.29) yrs | Asprosin:1.12 ± 0.43 μg/mL; TNF-α: 1.81 ± 0.65 pg/mL; Adiponectin:3.85 ± 1.78 μg/mL |
Moradi et al., 2023 [18] | Cross-sectional, case-controlled study; Iran | BMI higher than the 95th percentile related to age and gender entered the group with obesity. | Serum (overnight fasting 12–16 h); ELISA | 35 | BMI: (28.13 ± 5.75) kg/m2; Age: (132.57 ± 32.74) mo | Asprosin:8.65 ± 2.01 nmol/L; Visfatin: 2.09 ± 1.03 ng/mL; Metrnl: 72 ± 21.9 pg/mL | 35 | BMI: (18.41 ± 2.65) kg/m2; Age: (138.77 ± 25.65) mo | Asprosin:6.69 ± 1.97 nmol/L; Visfatin: 1.49 ± 0.87 ng/mL; Metrnl: 100 ± 27.84 pg/mL |